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. 2017 Nov 6;5(4):2324709617740906.
doi: 10.1177/2324709617740906. eCollection 2017 Oct-Dec.

Primary Carcinosarcoma of the Pancreas With CD10-Positive Sarcoma Component

Christine J Salibay  1 , Julia Rewerska  1 , Shweta Gupta  2 , Nicholas Ree  2
Affiliations

Primary Carcinosarcoma of the Pancreas With CD10-Positive Sarcoma Component

Christine J Salibay et al. J Investig Med High Impact Case Rep. .

Abstract

Carcinosarcomas of the pancreas are rare entities with a dismal prognosis. We report a rare case of pancreatic carcinosarcoma in a 49-year-old African American female who underwent a total abdominal hysterectomy with right salpingo-oophorectomy and exploration of the pancreatic mass. The surgery revealed a sclerotic mass in the body and tail of the pancreas that was surgically unresectable, and a pancreatic biopsy confirmed the pathology of pancreatic carcinosarcoma. Histologically, the lesion showed a high-grade spindle cell sarcoma and adjacent moderately differentiated adenocarcinoma. On immunohistochemical examination, the carcinomatous component was positive for epithelial markers, and the sarcomatous component was focally positive for SMA and desmin. In addition, the sarcomatous component showed diffuse immunoreactivity for CD10 with a surrounding myofibroblastic proliferation. Reports have associated expression of CD10 in pancreatic stellate cells with increased tumor aggressiveness. In this article, we report a case of pancreatic carcinosarcoma that shows sarcomatous CD10 immunoexpression with higher Ki67 labeling in the sarcoma than the carcinoma raising the question if the sarcomatous component could be potentiating the aggressiveness of the carcinomatous component.

Keywords: adenocarcinoma; carcinosarcoma; pancreatic; primary pancreatic.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
(A) The tumor was composed of an adenocarcinoma component (hematoxylin-eosin; magnification 200×). (B) An atypical sarcomatous component (hematoxylin-eosin; magnification 200×).
Figure 2.
Figure 2.
(A) Adenocarcinoma stained strongly for AE1/AE3 with negative stroma around the tumor (AE1/AE3 immunostain; magnification 200×). The stromal component was positive for (B) CD10 (CD10 immunostain; magnification 200×).
See this image and copyright information in PMC

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