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Comment
. 2017 Dec;92(6):1308-1311.
doi: 10.1016/j.kint.2017.10.005.

A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response

Christina M Wyatt  1 , Steven D Crowley  2
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Free article
Comment

A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response

Christina M Wyatt et al. Kidney Int. 2017 Dec.
Free article

Abstract

The extreme hypertonicity of the renal medulla plays a central role in regulating volume status. A recent publication in Cell has identified a novel role for the high sodium environment and the local epithelial cells in the recruitment of mononuclear phagocytes, potentially contributing to the defense against ascending urinary tract infection.

Keywords: chemokine; cytokines; diabetes insipidus; macrophages; pyelonephritis.

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