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Review
. 2018 Jan;14(1):65-74.
doi: 10.1016/j.hfc.2017.08.008.

Growth Hormone as Biomarker in Heart Failure

Alberto M Marra  1 , Emanuele Bobbio  2 , Roberta D'Assante  1 , Andrea Salzano  3 , Michele Arcopinto  2 , Eduardo Bossone  4 , Antonio Cittadini  5
Affiliations
Review

Growth Hormone as Biomarker in Heart Failure

Alberto M Marra et al. Heart Fail Clin. 2018 Jan.

Abstract

The impairment of growth hormone (GH)/insulin growth factor-1(IGF-1) plays a crucial role in chronic heart failure (CHF). Several studies have shown that patients affected by this condition display a more aggressive disease, with impaired functional capacity and poor outcomes. Interestingly, GH replacement therapy represents a possible future therapeutic option in CHF. In this review, the authors focus on the assessment of the main abnormalities in GH/IGF-1 axis in CHF, the underlying molecular background, and their impact on disease progression and outcomes.

Keywords: Anabolic deficiency; Biomarker; Chronic heart failure; Growth hormone; IGF-1; Outcomes.

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