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. 1989 Mar;63(3):1455-9.
doi: 10.1128/JVI.63.3.1455-1459.1989.

Genetic recombination of human immunodeficiency virus

F Clavel  1 , M D Hoggan, R L Willey, K Strebel, M A Martin, R Repaske
Affiliations

Genetic recombination of human immunodeficiency virus

F Clavel et al. J Virol. 1989 Mar.

Abstract

We investigated genetic recombination of the human immunodeficiency virus (HIV) in a tissue culture system. A clonal cell line expressing a single integrated HIV provirus with a termination codon affecting pol gene expression was transfected with different defective mutants derived from an infectious molecular clone of HIV. Replication-competent viral particles were recovered, passaged, and plaque purified. Restriction analyses of the proviral DNA corresponding to several of these viruses indicated that their emergence was the result of genetic recombination.

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References

    1. Virology. 1978 Jun 1;87(1):130-41 - PubMed
    1. J Mol Biol. 1967 Jun 14;26(2):365-9 - PubMed
    1. J Gen Virol. 1979 May;43(2):349-64 - PubMed
    1. J Virol. 1979 Jul;31(1):257-60 - PubMed
    1. J Exp Med. 1980 Feb 1;151(2):467-80 - PubMed

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