Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Dec;30(4):320-326.
doi: 10.1016/j.beha.2017.09.004. Epub 2017 Sep 22.

Impact of allogeneic hematopoietic cell transplantation on the outcome of older patients with acute myeloid leukemia

Frederick R Appelbaum  1
Affiliations
Review

Impact of allogeneic hematopoietic cell transplantation on the outcome of older patients with acute myeloid leukemia

Frederick R Appelbaum. Best Pract Res Clin Haematol. 2017 Dec.

Abstract

For younger patients with intermediate- or high-risk acute myeloid leukemia (AML) in first remission, allogeneic hematopoietic cell transplantation (HCT) offers the best chance of cure and therefore is the treatment of choice. The role of allogeneic HCT in the treatment of older patients is less well defined. In this review, four issues concerning the role of HCT in the treatment of older AML patients will be addressed: the frequency of allogeneic HCT in the older AML population in the US; the impact of age on the outcome of HCT; the comparative outcome of allogeneic HCT versus chemotherapy in older AML patients; and some of the barriers to the effective use of HCT in older AML patients.

Keywords: AML; Acute myeloid leukemia; Allogeneic; Elderly; HCT; Hematopoietic cell transplant.

PubMed Disclaimer

LinkOut - more resources