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Review
. 2018 Feb;36(1):1-11.
doi: 10.1016/j.ncl.2017.08.002.

Multiple Sclerosis: Mechanisms of Disease and Strategies for Myelin and Axonal Repair

Hernan Nicolas Lemus  1 , Arthur E Warrington  2 , Moses Rodriguez  3
Affiliations
Review

Multiple Sclerosis: Mechanisms of Disease and Strategies for Myelin and Axonal Repair

Hernan Nicolas Lemus et al. Neurol Clin. 2018 Feb.

Abstract

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system with a variety of presentations and unclear pathogenesis. Multiple sclerosis has been associated with the term autoimmunity as a surrogate for pathogenesis. Multiple sclerosis is an organ-specific disease with immune-mediated myelin destruction. Understanding the complex etiology of multiple sclerosis and the importance of axon integrity is critical for clinicians who treat the disease. This review discusses the immune and autoimmune aspects of multiple sclerosis based on the current published data and novel evidence of strategies that promote remyelination and protect axons.

Keywords: Autoimmune; Axon; Immune; Multiple sclerosis; Remyelination.

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Figures

Fig. 1
Fig. 1
Autoimmune response hypothesis for MS.
See this image and copyright information in PMC

References

    1. Lucchinetti C., Bruck W., Parisi J. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol. 2000;47(6):707–717. - PubMed
    1. Pelletier D., Hafler D.A. Fingolimod for multiple sclerosis. N Engl J Med. 2012;366(4):339–347. - PubMed
    1. Frohman E.M., Racke M.K., Raine C.S. Multiple sclerosis–the plaque and its pathogenesis. N Engl J Med. 2006;354(9):942–955. - PubMed
    1. Qin Y., Duquette P., Zhang Y. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest. 1998;102(5):1045–1050. - PMC - PubMed
    1. Ando D.G., Clayton J., Kono D. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol. 1989;124(1):132–143. - PubMed