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. 2017 May 4:85:15-19.
doi: 10.1016/j.curtheres.2017.04.007. eCollection 2017.

Current Condition of Chronic Hepatitis B Virus Infection in Cuban Adults

Castellanos Fernández Marlen Ivón  1 , Dorta Guridi Zaily  2 , Da Silva Conde-Eduardo Leda Patricia  2 , Galbán García Enrique  3 , Arús Soler Enrique  2 , Martinez Pérez Yadina  2
Affiliations

Current Condition of Chronic Hepatitis B Virus Infection in Cuban Adults

Castellanos Fernández Marlen Ivón et al. Curr Ther Res Clin Exp. .

Abstract

Background: The reduction of the incidence of hepatitis B virus (HBV) infection in Cuba can be attributed to the effectiveness of the national immunization program. However, the number of patients with chronic HBV observed in clinical practice is not negligible.

Objective: A cross-sectional study was conducted to describe the main clinical characteristics of patients with chronic hepatitis B virus infection.

Methods: A total of 146 patients who had at least a 6-month history of hepatitis B surface antigen positivity were recruited between 2013 and 2015. Descriptive statistical analysis of the epidemiologic, clinical, biochemical, and virologic variables was performed.

Results: Men accounted for 67.8% of patients, and the median age was 43 years. The median time since diagnosis of infection was 9 years. Among the patients, 59% had chronic hepatitis, 34% had liver cirrhosis, and 7% were inactive carriers. Concomitant diagnoses demonstrated that 16.4% of patients had malignancies, predominantly lymphoma. Only 64.4% of patients had received antiviral treatment, and lamivudine was the most commonly used (61.6%) drug. Moreover, 70% of patients were identified during an inactive phase.

Conclusions: Patients with chronic HBV infection are still a health problem in the adult Cuban population, especially in patients with concomitant malignancies.

Keywords: chronic hepatitis; hepatitis B; liver cirrhosis; malignancies.

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