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Editorial
. 2018 Mar 1;197(5):545-547.
doi: 10.1164/rccm.201711-2166ED.

Gene-Environment Interactions Associated with the Severity of Acute Asthma Exacerbation in Children

David B Kantor  1   2 , Wanda Phipatanakul  3   4 , Joel N Hirschhorn  5   6   7
Affiliations
Editorial

Gene-Environment Interactions Associated with the Severity of Acute Asthma Exacerbation in Children

David B Kantor et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Model of gene–environment interactions. (A) Acute asthma severity is increased when the susceptible CDHR3 genotype occurs together with a triggering environmental exposure, namely rhinovirus infection. Those homozygous for the CDHR3 risk allele (rs6967330-A) are about twice as likely to be hospitalized for asthma exacerbation by age 6 years as those who are homozygous for the wild-type allele (rs6967330-G) (9). Note that the phenotype associated with the CDHR3 risk allele is expressed only when it occurs together with the triggering environmental exposure. (B) The CDHR3 risk allele increases cell-surface expression of CDHR3, resulting in increased rhinovirus C binding and replication. Enhanced rhinovirus C virulence triggers a sequence of events leading to increased severity of acute asthma exacerbation. CDHR3 = cadherin-related family member 3.
See this image and copyright information in PMC

Comment on

References

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