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Review
. 2017 Nov 21;9(11):1268.
doi: 10.3390/nu9111268.

The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update

Carlo Catassi  1 , Armin Alaedini  2 , Christian Bojarski  3 , Bruno Bonaz  4 , Gerd Bouma  5 , Antonio Carroccio  6 , Gemma Castillejo  7 , Laura De Magistris  8 , Walburga Dieterich  9 , Diana Di Liberto  10 , Luca Elli  11 , Alessio Fasano  12 , Marios Hadjivassiliou  13 , Matthew Kurien  14 , Elena Lionetti  15 , Chris J Mulder  16 , Kamran Rostami  17 , Anna Sapone  18 , Katharina Scherf  19 , Detlef Schuppan  20 , Nick Trott  21 , Umberto Volta  22 , Victor Zevallos  23 , Yurdagül Zopf  24 , David S Sanders  25
Affiliations
Review

The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update

Carlo Catassi et al. Nutrients. .

Abstract

Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion.

Keywords: amylase-trypsin inhibitors (ATIs); celiac disease; gluten sensitivity; gluten-free diet; gluten-related disorders; wheat allergy.

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Conflict of interest statement

This paper was made possible by support from Schär for traveling and lodging sponsorship for all co-authors to meet to discuss the object of this paper.

Figures

Figure 1
Figure 1
Potential triggers in wheat that may account for both intestinal and extra-intestinal symptoms.
Figure 2
Figure 2
Wheat components.
Figure 3
Figure 3
IBS treatment pathway.
See this image and copyright information in PMC

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