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Comment
. 2017 Nov 20;27(22):R1233-R1236.
doi: 10.1016/j.cub.2017.10.004.

Endosomal Trafficking: Retromer and Retriever Are Relatives in Recycling

David C Gershlick  1 , María Lucas  2
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Endosomal Trafficking: Retromer and Retriever Are Relatives in Recycling

David C Gershlick et al. Curr Biol. .
Free article

Abstract

Transmembrane proteins are sorted from endosomes to avoid lysosomal degradation. A recent study has identified a new multimeric complex called retriever that is essential for recycling numerous cell-surface cargoes from endosomes and is structurally and functionally related to the well-characterised retromer complex.

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  • Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
    McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ. McNally KE, et al. Nat Cell Biol. 2017 Oct;19(10):1214-1225. doi: 10.1038/ncb3610. Epub 2017 Sep 11. Nat Cell Biol. 2017. PMID: 28892079 Free PMC article.

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