Re-cyclin' Cell-Cycle Components to Make NETs
- PMID: 29161586
- DOI: 10.1016/j.devcel.2017.11.002
Re-cyclin' Cell-Cycle Components to Make NETs
Abstract
Neutrophil extracellular traps (NETs) are critical for the clearance of large pathogens and are also implicated in thrombosis, autoimmunity, and cancer. In this issue of Developmental Cell, Amulic et al. (2017) show that the terminally differentiated, non-cycling neutrophils repurpose cell-cycle proteins and pathways to form NETs.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.Dev Cell. 2017 Nov 20;43(4):449-462.e5. doi: 10.1016/j.devcel.2017.10.013. Epub 2017 Nov 2. Dev Cell. 2017. PMID: 29103955
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