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Review
. 2017 Oct 30:8:1422.
doi: 10.3389/fimmu.2017.01422. eCollection 2017.

Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

Cornelia Symowski  1 , David Voehringer  1
Affiliations
Review

Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

Cornelia Symowski et al. Front Immunol. .

Abstract

Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths. ILC2s can interact with a variety of cells types of the innate and adaptive immune system by cell-cell contacts or by communication via soluble factors. In this review, we provide an overview about recent advances in our understanding how ILC2s orchestrate type 2 immune responses with focus on direct interactions between ILC2s and other cells of the immune system.

Keywords: Th2 cells; allergic inflammation; alternatively activated macrophages; basophils; eosinophils; helminths; innate lymphoid cells; mast cells.

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Figures

Figure 1
Figure 1
Interactions between innate lymphoid cells (ILC2s) and T cells or B cells. The figure illustrates how ILC2s interact with T cells or B cells as described in the main text. The dashed arrow indicates a potential feedback regulation for which there is currently no experimental evidence. Solid arrows indicate published evidence for activating mechanisms whereas Treg-derived IL-10 was shown to suppress ILC2s. Cell symbols where taken from http://smart.servier.com website.
Figure 2
Figure 2
Interactions between innate lymphoid cells (ILC2s) and cells of the innate immune system. The figure illustrates communication pathways between ILC2s and other cells of the innate immune system by secretion and recognition of soluble factors as described in the main text. Solid arrows indicate published evidence for activating mechanisms whereas ILC2-derived IL-13 was shown to suppress mast cells and IL-27 or interferons inhibit ILC2 functions. Cell symbols where taken from http://smart.servier.com website.
See this image and copyright information in PMC

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