Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May 26;22(1):49.
doi: 10.1186/s12199-017-0660-5.

Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function

Rishila Ghosh  1 , Manushi Siddarth  2 , Neeru Singh  1 , Vipin Tyagi  1 , Pawan Kumar Kare  1 , Basu Dev Banerjee  1 , Om Prakash Kalra  3 , Ashok Kumar Tripathi  4
Affiliations

Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function

Rishila Ghosh et al. Environ Health Prev Med. .

Abstract

Background: Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study.

Methods: All the recruited study subjects (n = 300) were divided in three groups, namely, healthy control (n = 100), patients with chronic kidney disease of unknown etiology (n = 100), and patients with chronic kidney disease of known etiology (CKDk) (n = 100). Blood OCP levels of all three study groups were analyzed by gas chromatography.

Results: Increased level of OCPs, namely α-HCH, aldrin, and β-endosulfan, were observed in CKDu patients as compared to healthy control and CKD patients of known etiology. The levels of these pesticides significantly correlated negatively with the estimated glomerular filtration rate (eGFR) and positively with urinary albumin of CKD patients. Logistic regression analysis revealed association of γ-HCH, p, p'-DDE, and β-endosulfan with CKDu on adjustment of age, sex, BMI, and total lipid content.

Conclusions: Increased blood level of certain organochlorine pesticides is associated with the development of chronic kidney disease of unknown etiology.

Keywords: Chronic kidney disease of unknown etiology; Organochlorine pesticides; Urinary albumin; eGFR.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lopez-Novoa JM, Rodriguez-Pena AB, Ortiz A, Martinez-Salgado C, Lopez Hernandez FJ. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications. J Transl Med. 2011;1479:9–13. - PMC - PubMed
    1. Rajapurkar MM, John GT, Kirpalani AL, Abraham G, Agarwal SK, Almeida AF. What do we know about chronic kidney disease in India: first report of the Indian CKD registry? BMC Nephrol. 2012;13:1–10. doi: 10.1186/1471-2369-13-10. - DOI - PMC - PubMed
    1. Herrera CR, Orantes M, Almaguer M, Alfonso P, Hector D, Bayarre ML. Clinical characteristics of chronic kidney disease of non-traditional causes in Salvadoran farming communities. MEDICC Rev. 2014;16:39–48. - PubMed
    1. Silva LC, Ordonez P. Chronic kidney disease in Central American agricultural communities: challenges for epidemiology and public health. MEDICC Rev. 2014;16:66–71. - PubMed
    1. Ruiz-Suarez LE, Castro-Chan RA, Rivero-Perez NE. Levels of organochlorine pesticides in blood plasma from residents of malaria-endemic communities in Chiapas, Mexico. Int J Environ Res Public Health. 2014;11:44–60. doi: 10.3390/ijerph111010444. - DOI - PMC - PubMed