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Review
. 2017 Nov 22;6(11):107.
doi: 10.3390/jcm6110107.

Knee and Ankle Arthroplasty in Hemophilia

Affiliations
Review

Knee and Ankle Arthroplasty in Hemophilia

Luigi Piero Solimeno et al. J Clin Med. .

Abstract

Today, major surgical procedures can be safely performed in hemophilic patients with chronic arthropathy, using available factor concentrates. In this setting, total knee replacement is considered the "gold standard", while the use of total ankle replacement is still debated. Indeed, the unsatisfactory results obtained with the previous available design of implants did not raise enthusiasm as knee or hip replacement. Recently, the introduction of new implant designs and better reported outcomes have renewed the interest in total ankle replacement in people with hemophilia. In this review, the role of replacement surgery in the treatment of chronic hemophilic arthropathy will be described.

Keywords: ankle; arthroplasty; hemophilia; knee; replacement.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Hakobyan N., Kazarian T., Jabbar K.J., Valentino L.A. Pathobiology of hemophilic synovitis I: Overexpression of mdm2 oncogene. Blood. 2004;104:2060–2064. doi: 10.1182/blood-2003-12-4231. - DOI - PubMed
    1. Valentino L.A., Hakobyan N., Kazarian T., Jabbar K.J., Jabbar A.A. Experimental haemophilic synovitis: Rationale and development of a murine model of human factor VIII deficiency. Haemophilia. 2004;10:280–287. doi: 10.1111/j.1365-2516.2004.00899.x. - DOI - PubMed
    1. Sokoloff L. Biochemical and physiological aspects of degenerative joint disease with special reference to hemophilic arthropathy. Am. N. Y. Acad. Sci. 1975;240:285–290. doi: 10.1111/j.1749-6632.1975.tb53362.x. - DOI - PubMed
    1. Roosendaal G., Vianen M.E., Wenting M.J.G., van Rinsum A.C., van den Berg H.M., Lafeber F.P.J.G., Bijlsma J.W.J. Iron deposits and catabolic properties of synovial tissue from patients with haemophilia. J. Bone Jt. Surg. 1998;80-B:540–545. doi: 10.1302/0301-620X.80B3.7807. - DOI - PubMed
    1. Ribbans W.J., Phillips M.A. Haemophilic ankle arthropathy. Clin. Orthop. 1996;328:39–45. doi: 10.1097/00003086-199607000-00009. - DOI - PubMed

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