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Case Reports
. 2017 Nov 23;377(21):2095-2096.
doi: 10.1056/NEJMc1712990.

Reduction of Loa loa Microfilaremia with Imatinib - A Case Report

Elise M O'Connell  1 , Thomas B Nutman  1
Affiliations
Case Reports

Reduction of Loa loa Microfilaremia with Imatinib - A Case Report

Elise M O'Connell et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Microfilarial Response to a 600-mg Dose of Imatinib in a Patient with Loa loa Infection
Loa loa counts are expressed as absolute microfilariae (mf) per milliliter and percentage of the pretreatment quantitative polymerase chain reaction (qPCR) cycle threshold. Day 0 represents the pretreatment microfilarial level in the blood (2250 mf per milliliter; 100% of the pretreatment qPCR cycle threshold of 26.5) in a patient with L. loa infection. Day 1 was the first day after the patient received treatment with imatinib. By day 4, a 1-log10 decrease in microfilarial level still had not occurred (719 mf per milliliter). The nadir microfilarial level (150 mf per milliliter) was attained on day 6, before the level started to rise again (392 mf per milliliter on day 11).
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References

    1. Scientific Working Group on Serious Adverse Events in Loa loa Endemic Areas. Report of a scientific working group on serious adverse events following Mectizan treatment of onchocerciasis in Loa loa endemic areas. Filaria J. 2003;2(Suppl 1):S2. - PMC - PubMed
    1. Herrick JA, Legrand F, Gounoue R, et al. Posttreatment reactions after single-dose diethylcarbamazine or ivermectin in subjects with Loa loa infection. Clin Infect Dis. 2017;64:1017–25. - PMC - PubMed
    1. Kamgno J, Pion SD, Chesnais CB, et al. A test-and-not-treat strategy for onchocerciasis in Loa loa–endemic areas. N Engl J Med. 2017;377:2044–52. - PMC - PubMed
    1. O’Connell EM, Bennuru S, Steel C, Dolan MA, Nutman TB. Targeting filarial Abl-like kinases: orally available, Food and Drug Administration-approved tyrosine kinase inhibitors are microfilaricidal and macrofilaricidal. J Infect Dis. 2015;212:684–93. - PMC - PubMed
    1. O’Connell EM, Kamenyeva O, Lustigman S, Bell A, Nutman TB. Defining the target and the effect of imatinib on the filarial c-Abl homologue. PLoS Negl Trop Dis. 2017;11(7):e0005690. - PMC - PubMed