The Silent Undertakers: Macrophages Programmed for Efferocytosis
- PMID: 29166582
- DOI: 10.1016/j.immuni.2017.10.010
The Silent Undertakers: Macrophages Programmed for Efferocytosis
Abstract
Two recent Immunity papers provide new insight into efferocytosis by tissue-resident macrophages. Baratin et al. (2017) identify a resident macrophage population in the T cell zone of lymph nodes responsible for the silent uptake of vast numbers of apoptotic cells. Roberts et al. (2017) find that resident macrophages can be programmed by local tissue signals not to respond to the nucleic acid of apoptotic cells.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node.Immunity. 2017 Aug 15;47(2):349-362.e5. doi: 10.1016/j.immuni.2017.07.019. Epub 2017 Aug 8. Immunity. 2017. PMID: 28801233
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