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Editorial
. 2017 Oct 27:4:86.
doi: 10.21037/sci.2017.10.01. eCollection 2017.

Nicotinamide: a novel treatment for age-related macular degeneration?

Peter D Westenskow  1
Affiliations
Editorial

Nicotinamide: a novel treatment for age-related macular degeneration?

Peter D Westenskow. Stem Cell Investig. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflict of interest to declare.

Figures

Figure 1
Figure 1
Anatomy of the outer retina and cardinal features of age-related macular degeneration (AMD). (A) The extraretinal choriocapillaris (CC) is divided from the retinal pigment epithelium (RPE) by Bruch’s membrane (BM). RPE provide critical support for photoreceptors; (B) features of AMD, arbitrarily numbered top to bottom, are as follows: (1) choriocapillaris drop out; (2) BM with lipids (green circles) and reduced diffusibility; (3) formation of drusen that also limits diffusibility; (4) RPE dysfunction/death; and (5) photoreceptor atrophy. Choroidal neovascularization characteristic of wet AMD, is not shown.
Figure 2
Figure 2
Putative disease pathways in AMD, and limitations of using iPS-RPE for AMD modeling. (A) Initiating factors combine and converge on photoreceptor cells (PRCs), RPE, Bruch’s Membrane (BM), and/or the choroid (C). Changes to these components initiate a cascade of intermediate disease mechanisms. (B) Red lines mark the limited events from which data can be obtained from iPS-RPE. Only genetic contributions are interrogated, and downstream effects propagated through early and intermediate stages can only be predicted. Reproduced with modifications and permission of the American Society for Clinical Investigation, from Bird AC, JCI 2010 (8); permission conveyed through the Copyright Clearance Center Inc.
See this image and copyright information in PMC

Comment on

References

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