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. 2018 Sep;10(3):456-465.
doi: 10.1007/s12602-017-9357-8.

In Silico and Experimental Data Claiming Safety Aspects and Beneficial Attributes of the Bacteriocinogenic Strain Enterococcus faecalis B3A-B3B

Alaa Al Seraih  1 , Yanath Belguesmia  2 , Benoit Cudennec  1 , John Baah  3 , Djamel Drider  1
Affiliations

In Silico and Experimental Data Claiming Safety Aspects and Beneficial Attributes of the Bacteriocinogenic Strain Enterococcus faecalis B3A-B3B

Alaa Al Seraih et al. Probiotics Antimicrob Proteins. 2018 Sep.

Abstract

This study aimed at comparing the genome of Enterococcus faecalis B3A-B3B, a bacteriocinogenic strain recently isolated from a healthy Iraqi infant to those of Enterococci of clinical and beneficial grades. The putative genes gelE, cpd, efaAfm, ccf, agg, and cob coding for virulence factors were detected in B3A-B3B strain, which meanwhile resulted to be non-cytotoxic, non-hemolytic, devoid of inflammatory effects, and sensitive to most of the antibiotics tested except for clindamycin and trimethoprim, which resistance is usually ascribed to intrinsic nature. B3A-B3B strain was remarkable for its hydrophobicity, auto-aggregation, adhesion to human Caco-2 cells, and survival in simulated gastrointestinal conditions, and cholesterol assimilation fulfilling therefore key beneficial attributes.

Keywords: Bacteriocin; Beneficial traits; Enterococcus faecalis; In silico analysis; Lactic acid bacteria.

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References

    1. FEMS Microbiol Lett. 2015 Apr;362(8):fnv012 - PubMed
    1. Adv Exp Med Biol. 1997;412:421-6 - PubMed
    1. Int J Food Microbiol. 2003 Dec 1;88(2-3):255-62 - PubMed
    1. Folia Microbiol (Praha). 2004;49(6):763-8 - PubMed
    1. Science. 2003 Mar 28;299(5615):2071-4 - PubMed

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