Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov 23;18(12):2509.
doi: 10.3390/ijms18122509.

Coxiella burnetii Lipopolysaccharide: What Do We Know?

Prasad Abnave  1 , Xavier Muracciole  2 , Eric Ghigo  3
Affiliations
Review

Coxiella burnetii Lipopolysaccharide: What Do We Know?

Prasad Abnave et al. Int J Mol Sci. .

Abstract

A small gram-negative bacterium, Coxiella burnetii (C. burnetii), is responsible for a zoonosis called Q fever. C. burnetii is an intracellular bacterium that can survive inside microbicidal cells like monocytes and macrophages by hijacking several functions of the immune system. Among several virulence factors, the lipopolysaccharide (LPS) of C. burnetii is one of the major factors involved in this immune hijacking because of its atypical composition and structure. Thus, the aim of this mini-review is to summarize the repressive effects of C. burnetii LPS on the antibacterial immunity of cells.

Keywords: Coxiella burnetii; Q fever; lipopolysaccharide; phagosome; virenose.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Maurin M., Benoliel A.M., Bongrand P., Raoult D. Phagolysosomal alkalinization and the bactericidal effect of antibiotics: The Coxiella burnetii paradigm. J. Infect. Dis. 1992;166:1097–1102. doi: 10.1093/infdis/166.5.1097. - DOI - PubMed
    1. Eldin C., Melenotte C., Mediannikov O., Ghigo E., Million M., Edouard S., Mege J.L., Maurin M., Raoult D. From Q fever to Coxiella burnetii infection: A paradigm change. Clin. Microbiol. Rev. 2017;30:115–190. doi: 10.1128/CMR.00045-16. - DOI - PMC - PubMed
    1. Maurin M., Raoult D. Q fever. Clin. Microbiol. Rev. 1999;12:518–553. - PMC - PubMed
    1. Houpikian P., Habib G., Mesana T., Raoult D. Changing clinical presentation of Q fever endocarditis. Clin. Infect. Dis. 2002;34:E28–E31. doi: 10.1086/338873. - DOI - PubMed
    1. Gimenez D.F. Staining rickettsiae in yolk-sac cultures. Stain Technol. 1964;39:135–140. doi: 10.3109/10520296409061219. - DOI - PubMed

MeSH terms