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. 2018 Mar 31;19(2):271-279.
doi: 10.4142/jvs.2018.19.2.271.

Control of type O foot-and-mouth disease by vaccination in Korea, 2014-2015

Jong-Hyeon Park  1 , Dongseob Tark  2 , Kwang-Nyeong Lee  1 , Ji-Eun Chun  1 , Hyang-Sim Lee  1 , Young-Joon Ko  1 , Soo-Jeong Kye  1 , Yong-Joo Kim  1 , Jae-Ku Oem  1 , Soyoon Ryoo  1 , Sung-Bin Lim  1 , Seo-Yong Lee  1 , Joo-Hyung Choi  1 , Mi-Kyeong Ko  1 , Su-Hwa You  1 , Myoung-Heon Lee  1 , Byounghan Kim  1
Affiliations

Control of type O foot-and-mouth disease by vaccination in Korea, 2014-2015

Jong-Hyeon Park et al. J Vet Sci. .

Abstract

On December 3, 2014, a type O foot-and-mouth disease (FMD) outbreak began in Korea. Although vaccinations were administered, FMD cases increased steadily for five months, and reached 185 cases by April 2015. Most of the affected animals were pigs, which are vulnerable to vaccination. The FMD virus belonged to the South-East Asia (SEA) topotype that had been observed three times in Korea between April 2010 and July 2014. However, the FMD virus isolated in December 2014 had a unique feature; that is, partial deletion of the 5´ non-coding region, a deletion not seen in previous SEA topotype isolates identified in Korea. We conclude that this outbreak included the introduction of a new FMD strain to Korea, and that Korea was now affected by genetically similar FMD virus strains that are related to those from neighboring countries.

Keywords: Korea; control; foot-and-mouth disease; vaccination.

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Conflict of interest statement

Conflict of Interest: The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1. Outbreak of foot-and-mouth disease (FMD) in Korea in 2014 and 2015. (A) Monthly progress of FMD cases. GG, Gyeonggi; GW, Gangwon; CN, Chungnam; CB, Chungbuk; GB, Gyeongbuk; GN, Gyeongnam; JN, Jeonnam; JB, Jeonbuk; SJ, Sejong city; IC, Incheon city. (B) Number of detected cases in cattle and pigs, and cumulative case numbers occurring after the first case.
Fig. 2
Fig. 2. Antibody prevalence against foot-and-mouth disease in 2014 and 2015 cases in South Korea. (A) Type O antibody prevalence obtained by structural protein (SP) antibody enzyme-linked immunosorbent assay in 2014 and 2015. (B) Detected number of nonstructural protein (NSP) antibody positive farms in 2014 and 2015.
Fig. 3
Fig. 3. Comparison of VP1 sequences of vaccine prototypes and foot-and-mouth disease (FMD) viral strains closely related to O/SKR/Dec/2014 with a phylogenetic tree showing viral FMD strains closely related to O/SKR/Dec/2014 (black dot). The O/TAI/Ban/60 strain (GenBank KM243030.1) is a similar strain to O 3039. The National Center for Biotechnology Information GenBank accession numbers for the virus strains are as follows: O/SKR/Apr/2010 (HM143846.1), O/SKR/1/2000 (AJ318854.1), O/SKR/1/2002 (AH012984.2), O/HLJOC12/03 (DQ119643.2), O/JPN/1/2010 (LC149719.1), O/SKR/Nov/2010 (KR401159.1), O/SKR/Dec-YJ/2010 (KF501487.1), O/SKR/Dec-YC/2010 (KR401160.1), O/SKR/Dec/2014 (KX162590.1), O/TAI/Ban/60 (KM243030.1), O TAW 98 (KJ606982.1), O1 Manisa (AY593823.1), O1 Campos (AJ320488.1), and O/GZ-MT/CHA/2013 (KJ646655). SEA, South-East Asia; ME-SA, Middle East and South Asia; CHA, China; HKN, Hong Kong; JPN, Japan; SKR, South Korea; TUR, Turkey; BRA, Brazil; TAI, Thailand; TAW, Taiwan. The scale bar indicates nucleotide substitutions per site.
Fig. 4
Fig. 4. Comparison of complete genome and VP1 sequences of the foot-and-mouth disease (FMD) viral strains closely related to O/SKR/Dec/2014. (A) Nucleotide similarity in FMD viral strains closely related to O/SKR/Dec/2014. (B) Amino acid similarity in FMD viral strains closely related to O/SKR/Dec/2014. (C) Nucleotide similarity between vaccine prototypes and O/SKR/Dec/2014. (D) Amino acid similarity between vaccine prototypes and O/SKR/Dec/2014. (E) Similarity between VP1 nucleotides and amino acids in the coding sequences of vaccine prototypes or wild type strains compared with O/SKR/Dec/2014. The National Center for Biotechnology Information GenBank accession number for the virus strain is as follows: O BFS (AY593816). ME-SA, Middle East and South Asia; SEA, South-East Asia.
Fig. 5
Fig. 5. Comparison of unique foot-and-mouth disease (FMD) viral strain sequences closely related to O/SKR/Dec/2014. (A) Alignment of 5′ non-coding region (NCR) among Korean isolates since 2010. The rectangular box represents the deleted region in the 5′ NCR downstream of the poly-C region. (B) Alignment of VP1 sequence among Korean isolates since 2010 and vaccine prototypes. The rectangular box represents the unique region in the matching sequences. National Center for Biotechnology Information GenBank accession numbers for the virus strains are as follows: O/SKR/Apr/2010 (HM143846.1), O/SKR/Nov/2010 (KR401159.1), O/SKR/Dec/2014 (KX162590.1), O/SKR/Jul/2014 (kvcc.hahis.go.kr), O1 Mansia (AY593823.1), O/TAI/Ban/60 (KM243030.1), O TAW 97 (AY593835.1), O1 Campos (AJ320488.1), O/GZ-MT/CHA/2013 (KJ646655).
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References

    1. Abdela N. Sero-prevalence, risk factors and distribution of foot and mouth disease in Ethiopia. Acta Trop. 2017;169:125–132. - PubMed
    1. Brito BP, Rodriguez LL, Hammond JM, Pinto J, Perez AM. Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014. Transbound Emerg Dis. 2017;64:316–332. - PubMed
    1. Cai C, Li H, Edwards J, Hawkins C, Robertson ID. Meta-analysis on the efficacy of routine vaccination against foot and mouth disease (FMD) in China. Prev Vet Med. 2014;115:94–100. - PubMed
    1. Hall TA. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl Acids Symp Ser. 1999;41:95–98.
    1. Kitching RP. Clinical variation in foot and mouth disease: cattle. Rev Sci Tech. 2002;21:499–504. - PubMed

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