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. 2018 Feb;90(2):132-133.
doi: 10.1016/j.diagmicrobio.2017.09.016. Epub 2017 Oct 5.

Acquisition of the mcr-1 gene by a high-risk clone of KPC-2-producing Klebsiella pneumoniae ST437/CC258, Brazil

Tanise Vendruscolo Dalmolin  1 , Andreza Francisco Martins  2 , Alexandre Prehn Zavascki  3 , Daiana de Lima-Morales  4 , Afonso Luís Barth  5
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Free article

Acquisition of the mcr-1 gene by a high-risk clone of KPC-2-producing Klebsiella pneumoniae ST437/CC258, Brazil

Tanise Vendruscolo Dalmolin et al. Diagn Microbiol Infect Dis. 2018 Feb.
Free article

Abstract

We identified one clinical isolate of K. pneumoniae harboring the mcr 1 (plasmid of IncX4 family) and blaKPC-2 (plasmid of IncFIB family) genes in southern Brazil. These findings highlight that K. pneumoniae isolates carrying both mcr-1 and blaKPC-2 may emergence as a serious threat to antimicrobial therapy.

Keywords: Carbapenems; Colistin; Klebsiella pneumoniae; Resistance genes.

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