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. 2018 May;48(5):1523-1529.
doi: 10.1007/s10803-017-3409-5.

Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

Maunoo Lee  1   2   3 , Jayasree Krishnamurthy  4 , Apryl Susi  4 , Carolyn Sullivan  4 , Gregory H Gorman  4 , Elizabeth Hisle-Gorman  4 , Christine R Erdie-Lalena  4 , Cade M Nylund  4
Affiliations

Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

Maunoo Lee et al. J Autism Dev Disord. 2018 May.

Abstract

Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn's disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD.

Keywords: Autism spectrum disorders (ASD); Crohn’s disease (CD); Inflammatory bowel disease (IBD); Ulcerative colitis (UC).

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References

    1. Biol Psychiatry. 2017 Mar 1;81(5):411-423 - PubMed
    1. BMC Gastroenterol. 2017 Jan 31;17 (1):23 - PubMed
    1. J Pediatr Gastroenterol Nutr. 2007 Feb;44(2):180-4 - PubMed
    1. Pediatr Neurol. 2008 Dec;39(6):392-8 - PubMed
    1. Curr Opin Pediatr. 2002 Oct;14(5):583-7 - PubMed

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