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Comment

. 2017 Nov;24(6).

doi: 10.1111/xen.12366. Epub 2017 Nov 23.

PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation

Marc Güell¹, Dong Niu^{1

2}, Yinan Kan¹, Haydy George¹, Tao Wang¹, I-Hsiu Lee¹, Gang Wang¹, George Church³, Luhan Yang¹

Affiliations

Affiliations

¹ eGenesis Inc., Boston, MA, USA.
² College of Animal Sciences, Zhejiang University, Hangzhou, China.
³ Department of Genetics, Harvard Medical School, Boston, MA, USA.

PMID: 29171094
DOI: 10.1111/xen.12366

Comment

PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation

Marc Güell et al. Xenotransplantation. 2017 Nov.

. 2017 Nov;24(6).

doi: 10.1111/xen.12366. Epub 2017 Nov 23.

Authors

Marc Güell¹, Dong Niu^{1

2}, Yinan Kan¹, Haydy George¹, Tao Wang¹, I-Hsiu Lee¹, Gang Wang¹, George Church³, Luhan Yang¹

Affiliations

¹ eGenesis Inc., Boston, MA, USA.
² College of Animal Sciences, Zhejiang University, Hangzhou, China.
³ Department of Genetics, Harvard Medical School, Boston, MA, USA.

PMID: 29171094
DOI: 10.1111/xen.12366

No abstract available

Keywords: pathogen transmission; porcine endogenous retroviruses.

PubMed Disclaimer

Comment on

Elimination of porcine endogenous retroviruses from pig cells.
Denner J. Denner J. Xenotransplantation. 2015 Nov-Dec;22(6):411-2. doi: 10.1111/xen.12210. Epub 2015 Nov 14. Xenotransplantation. 2015. PMID: 26566739 No abstract available.
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9.
Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang G, Luo Y, Qing Y, Jiao D, Zhao H, Zhou X, Wang S, Wei H, Güell M, Church GM, Yang L. Niu D, et al. Science. 2017 Sep 22;357(6357):1303-1307. doi: 10.1126/science.aan4187. Epub 2017 Aug 10. Science. 2017. PMID: 28798043 Free PMC article.
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9, editorial commentary.
Scobie L, Denner J, Schuurman HJ. Scobie L, et al. Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12363. Epub 2017 Nov 12. Xenotransplantation. 2017. PMID: 29131463 No abstract available.

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