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. 2018 Jan;48(1):59-70.
doi: 10.4070/kcj.2017.0058. Epub 2017 Nov 15.

Association of Syntax Score II with Contrast-induced Nephropathy and Hemodialysis Requirement in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Ibrahim Rencuzogullari  1 , Metin Çağdaş  2 , Süleyman Karakoyun  2 , Yavuz Karabağ  2 , Mahmut Yesin  3 , Mustafa Ozan Gürsoy  4 , İnanç Artaç  2 , Doğan İliş  2 , Süleyman Çağan Efe  5 , Kevser Tural  6 , Ibrahim Halil Tanboğa  7
Affiliations

Association of Syntax Score II with Contrast-induced Nephropathy and Hemodialysis Requirement in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Ibrahim Rencuzogullari et al. Korean Circ J. 2018 Jan.

Abstract

Background and objectives: Contrast-induced nephropathy (CIN) is a common complication of primary percutaneous coronary intervention (pPCI) and is associated with high mortality and morbidity and long hospital stay in patients with ST elevation myocardial infarction (STEMI). The Syntax Score (SS) has previously been studied in STEMI patients, and it was associated with increased CIN development and long-term mortality. This study investigates a possible relationship between CIN development and Syntax Score II (SSII) and compares SS and SSII by assessing CIN risk in STEMI patients treated with pPCI.

Methods: A total of 1,234 patients who underwent pPCI were divided into 2 groups according to CIN development. Patients with CIN were further divided into 2 groups according to whether or not they required hemodialysis. Reclassification tables, net reclassification improvement, and integrated discriminative improvement methods were used to assess the additive predictive value of SSII for predicting CIN.

Results: In the present study, 166 patients (13.5%) had CIN. Although both SS and SSII were significantly higher in CIN patients, only SSII was an independent predictor of CIN (odds ratio [OR], 1.031; 95% confidence interval [CI], 1.012-1.051; p<0.001) and hemodialysis requirement (OR, 1.078; 95% CI, 1.046-1.078; p<0.001). When comparing SSII and SS in their ability to determine CIN risk, we found SSII to have a reclassification improvement of 27.59% (p<0.001) and an integrated discrimination improvement of 9.1% (p<0.001).

Conclusions: The combination of clinical and anatomic variables can more accurately identify patients who are at high risk for CIN after pPCI. While SSII is harder to calculate than SS, it provides better prediction for CIN and hemodialysis requirement than SS.

Keywords: Contrast induced nephropathy.; ST segment elevation myocardial infarction; Syntax score II.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Figure 1
Figure 1
Survival curve comparison between patients with and without CIN during hospitalization. CIN = contrast-induced nephropathy.
Figure 2
Figure 2
ROC graphics to detect cutoff values of SS and SSII for CIN prediction. CIN = contrast-induced nephropathy; ROC = receiver operating characteristics; SS = Syntax Score; SSII = Syntax Score II.
Figure 3
Figure 3
ROC graphics to detect cutoff values of SSII for hemodialysis requirement. ROC = receiver operating characteristics; SSII = Syntax Score II.
See this image and copyright information in PMC

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