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. 2018 Jan 1:143:97-106.
doi: 10.1016/j.ejmech.2017.11.025. Epub 2017 Nov 10.

Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities

Noor-Ul-Amin Mohsin  1 , Werner Seebacher  2 , Johanna Faist  3 , Patrick Hochegger  3 , Marcel Kaiser  4 , Pascal Mäser  4 , Ferdinand Belaj  5 , Robert Saf  6 , Nadine Kretschmer  7 , Muaaz Alajlani  7 , Ivana Turek  7 , Adelheid Brantner  7 , Rudolf Bauer  7 , Franz Bucar  7 , Robert Weis  3
Affiliations

Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities

Noor-Ul-Amin Mohsin et al. Eur J Med Chem. .

Abstract

A series of N-benzyl tetrahydropiperidinylidene pyrrolidinium salts have been synthesized and investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxic effects. The antibacterial, antimycobacterial and anticancer potencies of selected compounds were examined, too. Physicochemical parameters were calculated and structure-activity-relationships are discussed.

Keywords: Anticancer; Antimicrobial; Antiprotozoal; Benzyl tetrahydropiperidinylidene ammonium salts.

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