Intracellular Signaling Pathways Involved in (S)- and (R)-Ketamine Antidepressant Actions
- PMID: 29173705
- PMCID: PMC5735822
- DOI: 10.1016/j.biopsych.2017.10.026
Intracellular Signaling Pathways Involved in (S)- and (R)-Ketamine Antidepressant Actions
Conflict of interest statement
T.D.G. has received consulting fees from Janssen Pharmaceuticals, and research funding from Janssen Pharmaceuticals and Roche Pharmaceuticals during the preceding three years. P.Z., and T.D.G. are listed as co-authors in patent applications related to the pharmacology and use of (
Comment on
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Mechanistic Target of Rapamycin-Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model.Biol Psychiatry. 2018 Jan 1;83(1):18-28. doi: 10.1016/j.biopsych.2017.05.016. Epub 2017 May 31. Biol Psychiatry. 2018. PMID: 28651788
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- Singh JB, Fedgchin M, Daly E, Xi L, Melman C, De Bruecker G, et al. Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study. Biol Psychiatry. 2016;80:424–431. - PubMed
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- Zhang JC, Li SX, Hashimoto K. R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine. Pharmacol Biochem Behav. 2014;116:137–141. - PubMed
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- Fukumoto K, Toki H, Iijima M, Hashihayata T, Yamaguchi J-i, Hashimoto K, et al. Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine. Journal of Pharmacology and Experimental Therapeutics. 2017;361:9–16. - PubMed
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