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Randomized Controlled Trial
. 2017 Dec;56(12):1034-1042.e1.
doi: 10.1016/j.jaac.2017.10.008. Epub 2017 Oct 14.

Targeted Family Intervention for Complex Cases of Pediatric Obsessive-Compulsive Disorder: A Randomized Controlled Trial

Tara S Peris  1 , Michelle S Rozenman  2 , Catherine A Sugar  3 , James T McCracken  2 , John Piacentini  2
Affiliations
Randomized Controlled Trial

Targeted Family Intervention for Complex Cases of Pediatric Obsessive-Compulsive Disorder: A Randomized Controlled Trial

Tara S Peris et al. J Am Acad Child Adolesc Psychiatry. 2017 Dec.

Abstract

Objective: Although evidence-based treatments for pediatric obsessive-compulsive disorder (OCD) exist, many youth fail to respond, and interventions tailored to the needs of specific subsets of patients are lacking. This study examines the efficacy of a family intervention module designed for cases of OCD complicated by poor family functioning.

Method: Participants were 62 youngsters aged 8 to 17 years (mean age = 12.71 years; 57% male; 65% white) with a primary diagnosis of OCD and at least 2 indicators of poor family functioning. They were randomized to receive 12 sessions of individual child cognitive-behavioral therapy (CBT) plus weekly parent psychoeducation and session review (standard treatment [ST]) or the same 12 child sessions plus 6 sessions of family therapy aimed at improving OCD-related emotion regulation and problem solving (positive family interaction therapy [PFIT]). Blinded raters evaluated outcomes and tracked responders to 3-month follow-up.

Results: Compared to ST, PFIT demonstrated better overall response rates on the Clinician Global Impression-Improvement scale (CGI-I; 68% versus 40%, p = .03, φ = 0.28) and rates of remission (58% PFIT versus 27% ST, p = .01, φ = 0.32). PFIT also produced significantly greater reductions in functional impairment, symptom accommodation, and family conflict, and improvements in family cohesion. As expected, these shifts in family functioning constitute an important treatment mechanism, with changes in accommodation mediating treatment response.

Conclusion: PFIT is efficacious for reducing OCD symptom severity and impairment and for improving family functioning. Findings are discussed in terms of personalized medicine and mechanisms of change in pediatric OCD treatment. Clinical trial registration information-Family Focused Treatment of Pediatric Obsessive Compulsive Disorder; http://clinicaltrials.gov/; NCT01409642.

Keywords: CBT; exposure; family treatment; pediatric OCD.

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Figures

Figure 1
Figure 1
Consort Diagram Study enrollment and retention. Note: PFIT = Positive Family Interaction Therapy, ST = Standard Treatment, FU = Follow-up.
Figure 2
Figure 2
Treatment response and obsessive-compulsive disorder (OCD) remission by group. Note: CGI-I = Clinical Global Impression Scale– Improvement; CYBOCS = Children’s Yale-Brown Obsessive Compulsive Scale; PFIT = Positive Family Interaction Therapy; ST = standard evidence-based treatment. * Indicates significant group differences (p < .05).
Figure 3
Figure 3
Obsessive-compulsive disorder severity and impairment by group from baseline to posttreatment. Note: Data presented for estimated marginal means from mixed models analysis. COIS-R = Child Obsessive-Compulsive Disorder (OCD) Impairment Scale – Parent-Report Revised; CYBOCS = Children’s Yale-Brown Obsessive Compulsive Scale; PFIT = Positive Family Interaction Therapy; ST = standard evidence-based treatment.
Figure 4
Figure 4
Family functioning outcomes by group from baseline to posttreatment. Note: Data presented for estimated marginal means from mixed models analysis. FAS = Family Accommodation Scale; FES = Family Environment Scale; PABS = Parental Attitudes and Behaviors Scale; PFIT = Positive Family Interaction Therapy; ST = standard evidence-based treatment.
See this image and copyright information in PMC

References

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