Re-examining Permissive Hypercapnia in ARDS: A Narrative Review

Abstract

Lung-protective ventilation (LPV) has become the cornerstone of management in patients with ARDS. A subset of patients is unable to tolerate LPV without significant CO₂ elevation. In these patients, permissive hypercapnia is used. Although thought to be benign, it is becoming increasingly evident that elevated CO₂ levels have significant physiological effects. In this narrative review, we highlight clinically relevant end-organ effects in both animal models and clinical studies. We also explore the association between elevated CO₂, acute cor pulmonale, and ICU mortality. We conclude with a brief review of alternative therapies for CO₂ management currently under investigation in patients with moderate to severe ARDS.

Keywords: ARDS; acute cor pulmonale; mechanical ventilation; permissive hypercapnia; right ventricular dysfunction.