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Clinical Trial
. 1989;36(1):91-2.
doi: 10.1007/BF00561032.

5-Methoxypsoralen increases evening sleepiness in humans: possible involvement of the melatonin secretion

E Souêtre  1 , E Salvati, J L Belugou, B Krebs, G Darcourt
Affiliations
Clinical Trial

5-Methoxypsoralen increases evening sleepiness in humans: possible involvement of the melatonin secretion

E Souêtre et al. Eur J Clin Pharmacol. 1989.

Abstract

The acute and short-term effect of 5-methoxypsoralen (5-MOP) on daytime sleepiness was investigated in 12 healthy subjects according to a double-blind cross-over design. 5-MOP (40 mg/day) or placebo was orally administered (one week each) at 16.00 h. 5-MOP significantly increases daytime sleepiness 4 to 5 h after administration without affecting the subsequent sleep efficiency and duration. We found a positive correlation between sleepiness and melatonin levels. Our findings suggest that the melatonin secretion may play a role in the effect of 5-MOP on sleepiness in humans.

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