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Review
. 2018 Feb;31(1):55-60.
doi: 10.1097/ACO.0000000000000549.

Vitamin C in sepsis

Sven-Olaf Kuhn  1 , Konrad Meissner  1 , Lena M Mayes  2 , Karsten Bartels  2
Affiliations
Review

Vitamin C in sepsis

Sven-Olaf Kuhn et al. Curr Opin Anaesthesiol. 2018 Feb.

Abstract

Purpose of review: This narrative review summarizes recent insights into the role of vitamin C in sepsis.

Recent findings: Septic shock remains a major source of morbidity and mortality in critically ill patients. Although many nutritional supplements have previously been tested unsuccessfully, vitamins are still being explored as a therapeutic option in septic patients. In particular, vitamin C-containing regimens as adjunctive therapy in sepsis have received much attention.

Summary: In-vitro evidence supports a critical role for vitamin C in cellular mechanisms relevant to the pathophysiology of sepsis. However, whether this justifies therapeutic use of vitamin C in septic patients remains uncertain.

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Conflict of interest statement

Conflict of Interest

None

Figures

Figure 1
Figure 1
In animal models of increased vascular permeability, vitamin C restores endothelial integrity and capillary function.
See this image and copyright information in PMC

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