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Comment
. 2018 Jul;15(7):651-653.
doi: 10.1038/cmi.2017.96. Epub 2017 Nov 27.

Crucial role of miR-31 in induction of CD8+ T-cell exhaustion and reinforcement of type 1 interferon signaling

Lin Ying Li  1 , Inkyu Hwang  2
Affiliations
Comment

Crucial role of miR-31 in induction of CD8+ T-cell exhaustion and reinforcement of type 1 interferon signaling

Lin Ying Li et al. Cell Mol Immunol. 2018 Jul.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
In wild-type mice, miR-31 expressed in CD8+ T cells following TCR recognition and costimulatory receptor–ligand interactions binds to its target mRNAs, including Ppp6c mRNA, which encodes a phosphatase involved in downregulation of type I IFN (IFN-α/β) signaling. As a result, the magnitude of type I IFN signal is escalated, resulting in increase in the expression of T-cell inhibitory receptors such as PD-1 that plays a critical role in the induction of T-cell exhaustion. In miR-31-deficient mice, the level of Ppp6c mRNA remains high, and the magnitude of type I IFN signal is kept under control. As a result, CD8+ T cells remain functionally competent.
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