Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Dec;14(12):1023-1025.
doi: 10.1038/cmi.2017.125. Epub 2017 Nov 27.

Amino acids 89-96 of Salmonella flagellin: a key site for its adjuvant effect independent of the TLR5 signaling pathway

Xilong Kang  1   2   3   4 , Zhiming Pan  1   2   3   4 , Xinan Jiao  1   2   3   4
Affiliations
Comment

Amino acids 89-96 of Salmonella flagellin: a key site for its adjuvant effect independent of the TLR5 signaling pathway

Xilong Kang et al. Cell Mol Immunol. 2017 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
TLR5-independent adjuvanticity of flagellin aa 89–96. The structure of Salmonella typhimurium flagellin is composed of two highly conserved domains (D0 and D1) and one central hypervariable domain (D2/D3). Amino acids 89–96 of flagellin (located in the D1 domain) constitute both the crucial site responsible for the humoral immune adjuvant effect and the TLR5 recognition site. However, the adjuvanticity is not dependent on typical TLR5 binding.
See this image and copyright information in PMC

Comment on

References

    1. Li W, Yang J, Zhang E, Zhong M, Xiao Y, Yu J et al. Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin. Cell Mol Immunol 2016; 13: 514–523. - PMC - PubMed
    1. Tallant T, Deb A, Kar N, Lupica J, de Veer MJ, DiDonato JA. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiol 2004; 4: 33. - PMC - PubMed
    1. Zhao Y, Shao F. The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus. Immunol Rev 2015; 265: 85–102. - PubMed
    1. Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL et al. Structural basis of TLR5-flagellin recognition and signaling. Science 2012; 335: 859–864. - PMC - PubMed
    1. Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA et al. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol 2008; 9: 1171–1178. - PMC - PubMed

LinkOut - more resources