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. 2018 Feb;7(2):65-68.
doi: 10.1002/psp4.12262. Epub 2017 Nov 27.

Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

Benjamin Schneider  1 , Violeta Balbas-Martinez  2 , Albert E Jergens  3 , Inaki F Troconiz  2 , Karin Allenspach  3 , Jonathan P Mochel  1
Affiliations

Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

Benjamin Schneider et al. CPT Pharmacometrics Syst Pharmacol. 2018 Feb.

Abstract

There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This "reverse translational" approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species.

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Figures

Figure 1
Figure 1
Translational vs. reverse translational sciences. Reverse translational sciences is a bidirectional approach in which clinical findings from patients are used to design early studies in relevant animal models of (spontaneous) disease. The information generated in animal studies will later be used to predict the efficacy and safety of future therapeutics in human clinical trials.
See this image and copyright information in PMC

References

    1. Waring, M.J. et al An analysis of the attrition of drug candidates from four major pharmaceutical companies. Nat. Rev. Drug Discov. 14, 475–486 (2015). - PubMed
    1. National Center for Emerging and Zoonotic Infectious Diseases (17 May 2012) . Centers for Disease Control and Prevention. <https://www.cdc.gov/ncezid/index.html> (2012).
    1. Jacob, J.A. Researchers turn to canine clinical trials to advance cancer therapies. JAMA 315, 1550–1552 (2016). - PubMed
    1. Gordon, I. , Paoloni, M. , Mazcko, C. & Khanna, C. The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway. PLoS Med. 6, e1000161 (2009). - PMC - PubMed
    1. Paoloni, M. et al Defining the pharmacodynamic profile and therapeutic index of NHS‐IL12 immunocytokine in dogs with malignant melanoma. PLoS One 10, e0129954 (2015). - PMC - PubMed

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