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Practice Guideline
. 2017 Nov 27;189(47):E1448-E1458.
doi: 10.1503/cmaj.170494.

Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis

Darrell H S Tan  1 , Mark W Hull  2 , Deborah Yoong  2 , Cécile Tremblay  2 , Patrick O'Byrne  2 , Réjean Thomas  2 , Julie Kille  2 , Jean-Guy Baril  2 , Joseph Cox  2 , Pierre Giguere  2 , Marianne Harris  2 , Christine Hughes  2 , Paul MacPherson  2 , Shannon O'Donnell  2 , Joss Reimer  2 , Ameeta Singh  2 , Lisa Barrett  2 , Isaac Bogoch  2 , Jody Jollimore  2 , Gilles Lambert  2 , Bertrand Lebouche  2 , Gila Metz  2 , Tim Rogers  2 , Stephen Shafran  2 ; Biomedical HIV Prevention Working Group of the CIHR Canadian HIV Trials Network
Affiliations
Practice Guideline

Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis

Darrell H S Tan et al. CMAJ. .

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Conflict of interest statement

Competing interests: Darrell Tan reports grants from the Canadian Institutes of Health Research and Ontario HIV Treatment Network, during the conduct of the study, and personal fees from Merck and GSK and grants and personal fees from Gilead and ViiV Healthcare, outside the submitted work. Mark Hull reports receiving honoraria for advisory board representation and speaking engagements regarding HIV and the hepatitis C virus from BMS, Gilead, Merck and ViiV Healthcare, paid to his institution. Deborah Yoong reports personal fees from Merck and Gilead Science, outside the submitted work. Cécile Tremblay reports grants and personal fees from Gilead, Merck, ViiV Healthcare, the Canadian Institutes of Health Research and Fonds de recherche santé Québec, both during the conduct of the study and outside the submitted work. Réjean Thomas reports personal fees from Gilead, outside the submitted work. Jean-Guy Baril reports grants from Gilead, Merck and Glaxo, and personal fees from Gilead, Merck and ViiV Healthcare, outside the submitted work. Joseph Cox reports grants and personal fees from ViiV Healthcare, and grants from Merck and Gilead, outside the submitted work. Pierre Giguere reports grants and personal fees from Gilead Sciences, ViiV Healthcare and Merck outside the submitted work. Marianne Harris reports grants and personal fees from Gilead Sciences Canada and personal fees from Merck Canada and ViiV Healthcare, outside the submitted work. Christine Hughes reports grants and personal fees from ViiV Healthcare, and personal fees from Merck Canada and Gilead Sciences Canada, outside the submitted work. Stephen Shafran reports grants from AbbVie, Gilead and Janssen; grants and personal fees from Merck and BMS; and personal fees from Pfizer, outside the submitted work. No other competing interests were declared.

References

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    1. Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001;357:1149–53. - PubMed
    1. Rodger AJ, Cambiano V, Bruun T, et al. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. JAMA 2016;316:171–81. - PubMed
    1. Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011;365:493–505. - PMC - PubMed
    1. Patel P, Borkowf CB, Brooks JT, et al. Estimating per-act HIV transmission risk: a systematic review. AIDS 2014;28:1509–19. - PMC - PubMed

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