Chitotriosidase: shucking the role of microglia in amyotrophic lateral sclerosis

Henrik Zetterberg^{1

2

3

4}

Affiliations

¹ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
² Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
³ Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
⁴ UK Dementia Research Institute at UCL, London, UK.

PMID: 29180539
DOI: 10.1136/jnnp-2017-317379

Editorial

Chitotriosidase: shucking the role of microglia in amyotrophic lateral sclerosis

Henrik Zetterberg. J Neurol Neurosurg Psychiatry. 2018 Mar.

. 2018 Mar;89(3):228-229.

doi: 10.1136/jnnp-2017-317379. Epub 2017 Nov 27.

Author

Henrik Zetterberg^{1

2

3

4}

Affiliations

¹ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
² Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
³ Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
⁴ UK Dementia Research Institute at UCL, London, UK.

PMID: 29180539
DOI: 10.1136/jnnp-2017-317379

No abstract available

Keywords: csf; motor neuron disease.

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Conflict of interest statement

Competing interests: None declared.

Comment on

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.
Steinacker P, Verde F, Fang L, Feneberg E, Oeckl P, Roeber S, Anderl-Straub S, Danek A, Diehl-Schmid J, Fassbender K, Fliessbach K, Foerstl H, Giese A, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer GB, Lauer M, Pinkhardt EH, Prudlo J, Rosenbohm A, Schneider A, Schroeter ML, Tumani H, von Arnim CAF, Weishaupt J, Weydt P, Ludolph AC, Yilmazer Hanke D, Otto M; FTLDc study group. Steinacker P, et al. J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):239-247. doi: 10.1136/jnnp-2017-317138. Epub 2017 Nov 15. J Neurol Neurosurg Psychiatry. 2018. PMID: 29142138

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Chitotriosidase: shucking the role of microglia in amyotrophic lateral sclerosis

Affiliations

Chitotriosidase: shucking the role of microglia in amyotrophic lateral sclerosis

Author

Affiliations

Conflict of interest statement

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