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. 2017 Nov 13:10:5429-5437.
doi: 10.2147/OTT.S149197. eCollection 2017.

The effect of CYP2D6 *10 polymorphism on adjuvant tamoxifen in Asian breast cancer patients: a meta-analysis

Junjun Lu #  1 , He Li #  2 , Peng Guo  1 , Rui Shen  3 , Yingbin Luo  1 , Qiao Ge  4 , Wenfei Shi  1 , Yan Li  1 , Weikang Zhu  1
Affiliations

The effect of CYP2D6 *10 polymorphism on adjuvant tamoxifen in Asian breast cancer patients: a meta-analysis

Junjun Lu et al. Onco Targets Ther. .

Abstract

Objective: To evaluate the effect of CYP2D6 *10 polymorphism (C 100C>T, rs1065852) on clinical outcomes of female Asian breast cancer patients with tamoxifen adjuvant treatment.

Methods: Meta-analysis of retrospective cohort studies published in July 2017 was performed. Fifteen studies with 1,794 Asian breast cancer patients were included, using strict eligibility requirements. Associations of disease-free survival (DFS), overall survival (OS) and recurrence rate after tamoxifen intake, with CYP2D6 *10 polymorphism were investigated through random effects models.

Results: CYP2D6 *10 polymorphism was found to have effect on DFS and recurrence rate in various comparison models, but not on overall survival in the female Asian breast cancer patients.

Conclusion: In conclusion, our meta-analysis suggests that significant association of *10/*10 (TT) genotype with poorer DFS and recurrence exists in female Asian breast cancer patients with tamoxifen 20 mg/day adjuvant treatment. In the future, large and well-designed studies are required to illustrate the interactions of CYP2D6 genetic variants, including *10 polymorphism and tamoxifen response on female breast cancer patients.

Keywords: Asia; CYP2D6 *10; breast cancer; polymorphism; tamoxifen adjuvant treatment.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Study flow diagram for the process of selecting the final 15 studies.
Figure 2
Figure 2
Forest plot to estimate the effect of CYP2D6 *10 polymorphism on the DFS of breast cancer patients taking tamoxifen. Note: Weights are from random effects analysis. Abbreviations: DFS, disease-free survival; HR, hazard ratio.
Figure 3
Figure 3
Forest plot to estimate the effect of CYP2D6 *10 polymorphism on the recurrence of breast cancer in patients taking tamoxifen in the comparison of (A) TT vs CC; (B) CT/TT vs CC; (C) TT vs CT/TT and (D) T vs C allele. Note: Weights are from random effects analysis. Abbreviations: CI, confidence interval; OR, odds ratio.
Figure 4
Figure 4
Begg’s funnel plots to examine publication bias for reported comparisons of CYP2D6 *10 polymorphism with recurrence in the comparison of (A) CT vs CC and (B) TT vs CC in Asian breast cancer patients treated with tamoxifen. Abbreviations: OR, odds ratio; SE, standard error.
Figure 5
Figure 5
Sensitivity analysis of the comparison of allele genetic model (T vs C allele) in the recurrence analysis.
See this image and copyright information in PMC

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References

    1. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) Davies C, Godwin J, et al. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet. 2011;378(9793):771–784. - PMC - PubMed
    1. Fabian C, Tilzer L, Sternson L. Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: correlation with blood levels in patients with metastatic breast cancer. Biopharm Drug Dispos. 1981;2(4):381–390. - PubMed
    1. Klein DJ, Thorn CF, Desta Z, Flockhart DA, Altman RB, Klein TE. PharmGKB summary: tamoxifen pathway, pharmacokinetics. Pharmacogenet Genomics. 2013;23(11):643–647. - PMC - PubMed
    1. Kiyotani K, Mushiroda T, Imamura CK, et al. Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J Clin Oncol. 2010;28(8):1287–1293. - PMC - PubMed
    1. Schroth W, Goetz MP, Hamann U, et al. Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA. 2009;302(13):1429–1436. - PMC - PubMed