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. 2017 Oct;13(6):1399-1407.
doi: 10.5114/aoms.2016.57677. Epub 2016 May 5.

Application of artificial neural networks for predicting presence of non-sentinel lymph node metastases in breast cancer patients with positive sentinel lymph node biopsies

Tomasz Nowikiewicz  1   2 , Paweł Wnuk  3 , Bogdan Małkowski  4 , Andrzej Kurylcio  5 , Janusz Kowalewski  3 , Wojciech Zegarski  2
Affiliations

Application of artificial neural networks for predicting presence of non-sentinel lymph node metastases in breast cancer patients with positive sentinel lymph node biopsies

Tomasz Nowikiewicz et al. Arch Med Sci. 2017 Oct.

Abstract

Introduction: The aim of this study was to present a new predictive tool for non-sentinel lymph node (nSLN) metastases.

Material and methods: One thousand five hundred eighty-three patients with early-stage breast cancer were subjected to sentinel lymph node biopsy (SLNB) between 2004 and 2012. Metastatic SLNs were found in 348 patients - the retrospective group. Selective axillary lymph node dissection (ALND) was performed in 94% of cases. Involvement of the nSLNs was identified in 32.1% of patients following ALND. The correlation between nSLN involvement and selected epidemiological data, primary tumor features and details of the diagnostic and therapeutic management was examined in metastatic SLN group. Multivariate analysis was performed using an artificial neural network to create a new nomogram. The new test was validated using the overall study population consisting of the prospective group (365 patients - SLNB between 01-07.2013).

Results: Accuracy of the new test was calculated using area under the receiver operating characteristics curve (AUC). We obtained AUC coefficient equal to 0.87 (95% confidence interval: 0.81-0.92). Sensitivity amounted to 69%, specificity to 86%, accuracy - 80% (retrospective group) and 77%, 46%, 66% (validation group), respectively. The Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram the calculated AUC value was 0.71, for Stanford - 0.68, for Tenon - 0.67.

Conclusions: In the analyzed group only the MSKCC nomogram and the new model showed AUC values exceeding the expected level of 0.70. Our nomogram performs well in prospective validation on patient series. The overall assessment of clinical usefulness of this test will be possible after testing it on different patient populations.

Keywords: breast cancer; nomogram; non-sentinel node metastases; sentinel lymph node biopsy.

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Figures

Figure 1
Figure 1
Patients treated by sentinel lymph node biopsy – nodal metastatic lesions – retrospective group
Figure 2
Figure 2
ROC curve – new nomogram – BRDA (AUC = 0.879)
Figure 3
Figure 3
ROC curve – MSKCC nomogram (AUC = 0.713)
Figure 4
Figure 4
ROC curve – Stanford nomogram (AUC = 0.676)
Figure 5
Figure 5
ROC curve – Tenon nomogram (AUC = 0.666)
See this image and copyright information in PMC

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