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. 2017 Nov;7(5):880-884.
doi: 10.3892/mco.2017.1391. Epub 2017 Aug 25.

Claudin-1 expression in cervical cancer

Friederike Hoellen  1 , Annika Waldmann  2 , Constanze Banz-Jansen  3 , Uwe Holtrich  4 , Thomas Karn  4 , Martina Oberländer  5   6 , Jens K Habermann  5   6 , Mareike Hörmann  7 , Frank Köster  1 , Julika Ribbat-Idel  8 , Marc Thill  9 , Achim Rody  1 , Ahmed El-Balat  4 , Lars Hanker  1
Affiliations

Claudin-1 expression in cervical cancer

Friederike Hoellen et al. Mol Clin Oncol. 2017 Nov.

Abstract

Claudin-1 is a tight junction protein that has been demonstrated to be involved in tumorigenesis and tumor progression in various types of solid tumors. In the present study, the protein expression of claudin-1 in squamous cervical cancer tissues obtained from 106 patients was analyzed by immunohistochemistry. In addition, the grade of claudin-1 expression was analyzed for associations with certain clinicopathological parameters. A significant overexpression of claudin-1 was detected in the tumor cells, when compared with that in the peritumoral stroma. There was no significant association between claudin-1 expression and FIGO stage, tumor size, grading or the appearance of distant metastases. Cervical cancer patients scoring positive for claudin-1 protein expression tended to exhibit more lymph node metastasis (28.3%), compared with claudin-1-negative patients (7.1%). Regarding overall survival, the results of the present study suggest a better prognosis for claudin-1-negative patients. In order to elucidate whether claudin-1 overexpression has a significant prognostic impact on squamous cervical cancer, further studies are required.

Keywords: cervical cancer; claudin-1; immunohistochemistry; lymph node metastases; squamous cervical cancer; survival analysis.

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Figures

Figure 1.
Figure 1.
Claudin-1 expression according to the immunoreactivity score (Remmele and Stegner).
Figure 2.
Figure 2.
Intratumoral and peritumoral Claudin-1 scores (immunoreactivity score).
Figure 3.
Figure 3.
Intratumoral claudin-1 and p16 expression.
Figure 4.
Figure 4.
Overall survival according to the expression of claudin-1 (immunoreactivity score).
See this image and copyright information in PMC

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