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. 2017 Nov;7(5):919-927.
doi: 10.3892/mco.2017.1389. Epub 2017 Aug 23.

Expression and clinical significance of androgen receptor in bladder cancer: A meta-analysis

Jinbo Chen  1   2 , Yu Cui  1 , Peng Li  3 , Longfei Liu  1 , Chao Li  1 , Xiongbing Zu  1
Affiliations

Expression and clinical significance of androgen receptor in bladder cancer: A meta-analysis

Jinbo Chen et al. Mol Clin Oncol. 2017 Nov.

Abstract

Emerging evidence has demonstrated that androgen receptor (AR) is a promising therapeutic target for bladder cancer. However, the relationship between AR expression and its clinical significance remains controversial. The present in-depth meta-analysis aimed to investigate the correlation between AR expression and clinicopathological features, as well as prognostic value in bladder cancer. A systematic search was performed from PubMed, Web of Knowledge, Embase and the Cochrane Central Search Library by January 2017. The correlation between AR expression and tumor stage, tumor grade, recurrence free survival and progression free survival for patients with bladder cancer was evaluated. A total of 12 relevant studies with 1,652 patient samples were included. AR expression positively correlated with low tumor grade [odds ratio (OR), 1.95; 95% confidence interval (CI), 1.36-2.81], low tumor stage (OR, 2.06; 95% CI, 1.02-4.16) and low recurrence rate [hazard ratio (HR), 0.48; 95% CI, 0.31-0.75] in Caucasian patients. While, its expression had no significant impact on cancer susceptibility (OR, 1.62; 95% CI, 0.19-13.72; P=0.44) and progression-free survival (HR, 1.20; 95% CI, 0.86-1.66; P=0.77). The present meta-analysis indicated that AR expression correlates with tumor grade, clinical stage and recurrence rates in the specified population and classification system. Further studies are required to determine the precise role of AR in bladder cancer.

Keywords: androgen receptor; bladder cancer; meta-analysis; prognosis.

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Figures

Figure 1.
Figure 1.
Flow chart of articles reviewed and included in the present meta-analysis.
Figure 2.
Figure 2.
Forest plot of OR for bladder cancer susceptibility. Square indicates point estimate of each study. Size of square indicates relative contribution of each study. Solid horizontal line represents 95% CI of each study. The diamond indicates the pooled OR value. OR, odds ratio; CI, confidence interval.
Figure 3.
Figure 3.
Forest plot of OR for tumor grade. Square indicates point estimate of each study. Size of square indicates relative contribution of each study. The horizontal line crossing the square represents the 95% CI. The diamond indicates the pooled OR value. OR, odds ratio; CI, confidence interval.
Figure 4.
Figure 4.
Forest plot of OR for tumor stage. Square indicates point estimate of each study. Size of square indicates relative contribution of each study. Solid horizontal line represents 95% CI of each study. The diamond indicates the pooled OR value. OR, odds ratio; CI, confidence interval.
Figure 5.
Figure 5.
Forest plot of HR for recurrence-free survival. Square indicates point estimate of each study. Size of square indicates relative contribution of each study. The horizontal line crossing the square represents the 95% CI. The diamond indicates the pooled HR value. NI, non-invasive; MI, muscle invasive; HR, hazard ratio; CI, confidence interval.
Figure 6.
Figure 6.
Forest plot of HR for progression-free survival. Square indicates point estimate of each study. Size of square indicates relative contribution of each study. The horizontal line crossing the square represents the 95% CI. The diamond indicates the pooled HR value. NI, non-invasive; MI, muscle invasive; HR, hazard ratio; CI, confidence interval.
Figure 7.
Figure 7.
Funnel plot for potential publication bias of tumor stage.
See this image and copyright information in PMC

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