Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017:2017:6496727.
doi: 10.1155/2017/6496727. Epub 2017 Oct 18.

Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease

Glynis Byrne  1 , Greg Rosenfeld  2 , Yvette Leung  2 , Hong Qian  3 , Julia Raudzus  4 , Carlos Nunez  4 , Brian Bressler  2
Affiliations

Prevalence of Anxiety and Depression in Patients with Inflammatory Bowel Disease

Glynis Byrne et al. Can J Gastroenterol Hepatol. 2017.

Abstract

Background: Inflammatory bowel disease (IBD) patients are not routinely screened for depression and anxiety despite knowledge of an increased prevalence in people with chronic disease and negative effects on quality of life.

Methods: Prevalence of anxiety and depression was assessed in IBD outpatients through retrospective chart review. The presence of anxiety and/or depression was determined using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 self-report questionnaires or by diagnosis through psychiatric interview. Patient demographics, disease characteristics, and medication information were also collected. Multivariable analysis was used to determine associations between patient factors and depression and anxiety.

Results: 327 patient charts were reviewed. Rates of depression and anxiety were found to be 25.8% and 21.2%, with 30.3% of patients suffering from depression and/or anxiety. Disease activity was found to be significantly associated with depression and/or anxiety (p = 0.01). Females were more likely to have anxiety (p = 0.01).

Conclusion: A significant proportion of IBD patients suffer from depression and/or anxiety. The rates of these mental illnesses would justify screening and referral for psychiatric treatment in clinics treating this population. Patients with active disease are particularly at risk for anxiety and depression.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Percentage of patients found to have anxiety and/or depression at present with active and inactive disease. Error bars represent 95% CI.
See this image and copyright information in PMC

Comment in

References

    1. Clarke D. M., Currie K. C. Depression, anxiety and their relationship with chronic diseases: A review of the epidemiology, risk and treatment evidence. Med. J. Aust. 2009;190(7):S54–S60. - PubMed
    1. Patten S. B. Long-term medical conditions and major depression in a Canadian population study at waves 1 and 2. Journal of Affective Disorders. 2001;63(1-3):35–41. doi: 10.1016/S0165-0327(00)00186-5. - DOI - PubMed
    1. Graff L. A., Walker J. R., Bernstein C. N. Depression and anxiety in iflammatory bowel disease: a review of comorbidity and management. Inflammatory Bowel Diseases. 2009;15(7):1105–1118. doi: 10.1002/ibd.20873. - DOI - PubMed
    1. Zhang C. K., Hewett J., Hemming J., et al. The influence of depression on quality of life in patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 2013;19(8):1732–1739. doi: 10.1097/mib.0b013e318281f395. - DOI - PMC - PubMed
    1. Dimatteo M. R., Lepper H. S., Croghan T. W. Depression is a risk factor for noncompliance with medical treatment meta-analysis of the effects of anxiety and depression on patient adherence. JAMA Internal Medicine. 2000;160(14):2101–2107. doi: 10.1001/archinte.160.14.2101. - DOI - PubMed