doi: 10.1007/s00253-017-8648-z.
Epub 2017 Nov 27.
Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA
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- PMID: 29181568
- DOI: 10.1007/s00253-017-8648-z
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Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA
Appl Microbiol Biotechnol.
2018 Jan.
Abstract
Ten new pentangular polyphenols, namely amexanthomycins A-J (1-10) were isolated from the strain Amycolatopsis mediterranei S699∆rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A-C (1-3) showed inhibitory activity against human DNA topoisomerases.
Keywords: Amycolatopsis mediterranei S699; Pentangular polyphenols; Topoisomerase IIα inhibitor; min-PKS.
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