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. 2018 Jan;102(2):689-702.
doi: 10.1007/s00253-017-8648-z. Epub 2017 Nov 27.

Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA

Xiaomei Li  1 , Xingkang Wu  1 , Jing Zhu  2 , Yuemao Shen  3   4
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Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA

Xiaomei Li et al. Appl Microbiol Biotechnol. 2018 Jan.

Abstract

Ten new pentangular polyphenols, namely amexanthomycins A-J (1-10) were isolated from the strain Amycolatopsis mediterranei S699∆rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A-C (1-3) showed inhibitory activity against human DNA topoisomerases.

Keywords: Amycolatopsis mediterranei S699; Pentangular polyphenols; Topoisomerase IIα inhibitor; min-PKS.

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