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. 2017 Dec 15;19(24):6662-6665.
doi: 10.1021/acs.orglett.7b03387. Epub 2017 Nov 28.

Ruthenium-Catalyzed meta-Carboxylation

Helen L Barlow  1 , Christopher J Teskey  1 , Michael F Greaney  1
Affiliations

Ruthenium-Catalyzed meta-Carboxylation

Helen L Barlow et al. Org Lett. .

Abstract

The meta-carboxylation of arenes containing pyridine and other azine-directing groups is reported. Using carbon tetrabromide as the C1 source, ruthenium(III) trichloride catalysis enables functionalization of the arene meta-C-H position, affording carboxy methyl ester products after in situ reaction with methanol.

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