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Comparative Study
. 2017 Nov 28;10(1):634.
doi: 10.1186/s13104-017-2981-2.

Comparison of the clinical and microbiological characteristics of Campylobacter and Helicobacter bacteremia: the importance of time to blood culture positivity using the BACTEC blood culture systems

Kei Yamamoto  1 , Kayoko Hayakawa  2 , Maki Nagashima  2 , Kayo Shimada  3 , Satoshi Kutsuna  2 , Nozomi Takeshita  2 , Yasuyuki Kato  2 , Shuzo Kanagawa  2 , Koji Yamada  4 , Kazuhisa Mezaki  4 , Teruo Kirikae  3 , Norio Ohmagari  2
Affiliations
Comparative Study

Comparison of the clinical and microbiological characteristics of Campylobacter and Helicobacter bacteremia: the importance of time to blood culture positivity using the BACTEC blood culture systems

Kei Yamamoto et al. BMC Res Notes. .

Abstract

Objective: Campylobacter spp. and Helicobacter spp. are rare but important causes of bacteremia in humans. Distinguishing these bacteria is complicated because of their similar phenotypic profiles. We conducted clinical and microbiological investigations of Campylobacter spp. or Helicobacter spp. bacteremia. Patients diagnosed with bacteremia from 2008 to 2014 were included. The clinical and microbiological characteristics of Campylobacter spp. and Helicobacter spp. bacteremia were compared. The BACTEC system was used in blood cultures. A receiver operating characteristic curve was plotted based on the time to blood culture positivity.

Results: Sixteen cases of Helicobacter spp. bacteremia (patient age: 61 ± 18 years) and 14 cases of Campylobacter spp. bacteremia (patient age: 49 ± 21 years) were identified. Median time to blood culture positivity was longer for the Helicobacter spp. cases than the Campylobacter spp. cases (91.4 h vs 55.3 h, p < 0.01). A time to blood culture positivity > 75 h predicted Helicobacter spp. bacteremia with a sensitivity of 0.88 and a specificity of 0.93 (area under the receiver operating characteristic curve of 0.90). In conclusion, a time to blood culture positivity was useful in distinguishing Helicobacter spp. bacteremia from Campylobacter spp. bacteremia.

Keywords: BACTEC; Bacteremia; Campylobacter; Helicobacter; Spiral-shaped bacilli.

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Figures

Fig. 1
Fig. 1
ROC curve demonstrating the TTBP used to diagnose bacteremia caused by spiral-shaped bacteria. ROC obtained from the results that were positive for spiral-shaped bacteria, of the first isolation from each patient (a) and those of all isolations (b) for TTBP to diagnose bacteremia due to Helicobacter spp. AUC, area under the receiver operating characteristic curve
See this image and copyright information in PMC

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