Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov 8:10:431-440.
doi: 10.2147/CCID.S145195. eCollection 2017.

Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®)

Francisco de Melo  1 , Pierre Nicolau  2 , Luca Piovano  3 , Shang-Li Lin  4 , Tiago Baptista-Fernandes  5 , Martyn I King  6 , Alessandra Camporese  7 , Kyungkook Hong  8 , Maria M Khattar  9 , Marie-Odile Christen  10
Affiliations
Review

Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®)

Francisco de Melo et al. Clin Cosmet Investig Dermatol. .

Abstract

Background: The range of fillers currently available for soft-tissue augmentation is constantly expanding. The latest advances in filler technology include collagen biostimulators that exert their esthetic effect by promoting neocollagenesis. One such product is the next-generation collagen biostimulator (Ellansé®) that demonstrates properties as yet unseen in soft-tissue fillers. It is composed of polycaprolactone (PCL) microspheres in an aqueous carboxymethylcellulose gel carrier. Given its specific characteristics and the number of areas that can be treated with this innovative product, experts' recommendations were deemed necessary and are therefore presented in this paper with a specific focus on the indications, treatment areas and procedures as well as injection techniques.

Methods: A multinational, multidisciplinary group of plastic surgeons and dermatologists convened to develop recommendations with a worldwide perspective. This publication provides information on the specific characteristics of the product and focuses on the recommendations on the injection techniques.

Results: Recommendations on injection techniques are provided for the upper face, mid-face and lower face and zone by zone for each of these areas, as well as hands. Based on the particular anatomy of each area, the focus is on the techniques and devices of injection and the volume and depth of injection. The information is tabulated, and photos are presented for illustration.

Conclusion: These recommendations provide a guideline for physicians who wish to perform safe and efficacious treatment with the PCL collagen stimulator for face and rejuvenation with volume augmentation.

Keywords: collagen stimulator; dermal filler; expert recommendations; injection techniques; polycaprolactone-Ellansé®; volumizer.

PubMed Disclaimer

Conflict of interest statement

Disclosure Drs. de Melo, Piovano, Baptista-Fernandes, Camporese, Hong, Khattar and Mrs Christen are consultants to Sinclair Pharmaceuticals. Dr Nicolau is a medical advisor at Sinclair Pharmaceuticals. Dr Poivano is a member of the IBSA academy. Dr Camporese is a consultant to Anteis, and Dr King is a consultant to Teoxane and a member of the medical esthetic group. Dr Lin has no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Individual facial treatment areas using the PCL-based stimulator. Notes: The PCL-based stimulator is an injectable implant, indicated for subdermal implantation in different areas of the face and in the hands. It is not indicated as a treatment for lips, glabella or eyelids. Abbreviation: PCL, polycaprolactone.
Figure 2
Figure 2
Before and after pictures of patients treated with the new-generation PCL-based collagen stimulator. Notes: Case A, 33 year old; Ellansé®-S; 3 months after; case B, 63 year old; Ellansé-M; 3 months after; case C, 54 year old; Ellansé-M; 3 months after; case D, 61 year old; Ellansé-M; 3 months after. Courtesy of Dr Sophie Converset and Dr Shang-Li Lin. The patients have given their written consent for their photos to be published. Abbreviations: PCL, polycaprolactone; NLF, nasolabial fold.
See this image and copyright information in PMC

References

    1. Plasticsurgery . 2015 Plastic Surgery Statistics. American Society of Plastic Surgeons; 2017. [Accessed April 21, 2017]. Available from: https://www.plasticsurgery.org/news/plastic-surgery-statistics?sub=2015+....
    1. Johl SS, Burgett RA. Dermal filler agents: a practical review. Curr Opin Ophthalmol. 2006;17(5):471–479. - PubMed
    1. Eppley BL, Dadvand B. Injectable soft-tissue fillers: clinical overview. Plast Reconstr Surg. 2006;118(4):98e–106e. - PubMed
    1. Yutskovskaya Y, Kogan E, Leshunov E. A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler. J Drugs Dermatol. 2014;13(9):1047–1052. - PubMed
    1. Goldberg D, Guana A, Volk A, Daro-Kaftan E. Single-arm study for the characterization of human tissue response to injectable poly-L-lactic acid. Dermatol Surg. 2013;39(6):915–922. - PubMed

LinkOut - more resources