Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov 14:8:927.
doi: 10.3389/fphys.2017.00927. eCollection 2017.

Strategies Developed to Induce, Direct, and Potentiate Bone Healing

Anne-Margaux Collignon  1   2 , Julie Lesieur  1 , Christian Vacher  1   3 , Catherine Chaussain  1   2 , Gael Y Rochefort  1
Affiliations
Review

Strategies Developed to Induce, Direct, and Potentiate Bone Healing

Anne-Margaux Collignon et al. Front Physiol. .

Abstract

Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of these, are now developed to facilitate the vascularization and the engraftment of the constructs, to recreate ultimately a bone tissue with the same properties and characteristics of the native bone. In this review, we browse the existing strategies that are currently developed, using biomolecules, cells and biomaterials, to induce, direct and potentiate bone healing after injury and further discuss the biological processes associated with this repair.

Keywords: biomolecules; bone healing; bone regeneration; scaffold; stem cells.

PubMed Disclaimer

References

    1. Abou Neel E. A., Bozec L., Knowles J. C., Syed O., Mudera V., Day R., et al. . (2013). Collagen–emerging collagen based therapies hit the patient. Adv. Drug Deliv. Rev. 65, 429–456. 10.1016/j.addr.2012.08.010 - DOI - PubMed
    1. Alaee F., Virk M. S., Tang H., Sugiyama O., Adams D. J., Stolina M., et al. . (2014). Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model. J. Orthop. Res. 32, 197–203. 10.1002/jor.22498 - DOI - PubMed
    1. Algahtani M. S., Scurr D. J., Hook A. L., Anderson D. G., Langer R. S., Burley J. C., et al. . (2014). High throughput screening for biomaterials discovery. J. Control. Release 190, 115–126. 10.1016/j.jconrel.2014.06.045 - DOI - PubMed
    1. Alghamdi H. S., Bosco R., Both S. K., Iafisco M., Leeuwenburgh S. C. G., Jansen J. A., et al. . (2014). Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats. Biomaterials 35, 5482–5490. 10.1016/j.biomaterials.2014.03.069 - DOI - PubMed
    1. Atesok K., Li R., Stewart D. J., Schemitsch E. H. (2010). Endothelial progenitor cells promote fracture healing in a segmental bone defect model. J. Orthop. Res. 28, 1007–1014. 10.1002/jor.21083 - DOI - PubMed

LinkOut - more resources