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Review
. 2017 Oct;9(Suppl 13):S1373-S1382.
doi: 10.21037/jtd.2017.10.67.

Exosomes as diagnostic and predictive biomarkers in lung cancer

Pablo Reclusa  1 , Simona Taverna  1   2   3 , Marzia Pucci  1   2 , Elena Durendez  1   4 , Silvia Calabuig  5   6 , Paolo Manca  1 , María José Serrano  7   8 , Laure Sober  9   10 , Patrick Pauwels  9   10 , Antonio Russo  11 , Christian Rolfo  1
Affiliations
Review

Exosomes as diagnostic and predictive biomarkers in lung cancer

Pablo Reclusa et al. J Thorac Dis. 2017 Oct.

Abstract

The concept of exosomes has evolved from be considered garbage bags to the demonstration that exosomes could play very interesting roles and functions, from biomarkers detection to the potential of work as drug delivery systems. It has been widely proved that exosomes can contain key molecules important for the tumour development. The current review summarizes the latest investigations developed in the field of predictive exosomal biomarkers. The microRNAs (miRNAs) are the more known molecules due to their amount inside the exosomes and the sensitivity of the techniques available for their study. However, exosomal proteins, RNA and DNA are becoming an interesting and more feasible field of study due to the improvement in the techniques available for their analysis. In the future years, it is hoped that exosomes will become an established member of the liquid biopsies in the clinical practice due to their diagnostic and prognostic properties.

Keywords: Exosomes; biomarkers; drug resistance; liquid biopsies; non-small cell lung cancer (NSCLC).

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Detailed process of exosomes formation from the early endosome to the exosomes recreation. ESCRT, endosomal sorting complex required for transport.
See this image and copyright information in PMC

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