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. 2017 Nov;60(6):579-586.
doi: 10.5468/ogs.2017.60.6.579. Epub 2017 Oct 23.

Comorbidity of gynecological and non-gynecological diseases with adenomyosis and endometriosis

Eun Ji Choi  1 , Seong Beom Cho  2 , Sa Ra Lee  1 , Young Mi Lim  1 , Kyungah Jeong  1 , Hye-Sung Moon  1 , Hyewon Chung  1
Affiliations

Comorbidity of gynecological and non-gynecological diseases with adenomyosis and endometriosis

Eun Ji Choi et al. Obstet Gynecol Sci. 2017 Nov.

Abstract

Objective: Adenomyosis and endometriosis are relatively common gynecological diseases that exhibit many common features. This study identified gynecological and non-gynecological diseases that exhibited comorbidity with adenomyosis and endometriosis in Korean women.

Methods: We used Health Insurance Review and Assessment data from 2009 to 2011 and searched for adenomyosis and endometriosis (coded as N80.1 and D25 in International Classification of Disease, 10th revision [ICD-10], respectively). We selected records from patients who had independent disease occurrences in each year, and comorbidities were estimated using Fisher's exact test. We computed each year's similarities and combined 3 years' results using Fisher's P-value summation method.

Results: A total of 61,516 patients' data were collected during the study period. The prevalence of adenomyosis and endometriosis were similar each year: 12.4% and 9.3% in 2009, 12.5% and 9.4% in 2010 and 13.3% and 9.1% in 2011, respectively. Meta-analysis revealed that 31 ICD-10 codes were significantly related with adenomyosis, and 44 ICD-10 codes were related with endometriosis. Gynecological diseases, such as leiomyoma and benign ovarian tumor, were significantly related to adenomyosis and endometriosis. Non-gynecological diseases, such as anemia and hypercholesterolemia, were also related to adenomyosis and endometriosis.

Conclusion: We must monitor for the presence of gynecological and non-gynecological diseases with co-morbidities during evaluations and follow-up of patients with adenomyosis or endometriosis.

Keywords: Adenomyosis; Anemia; Comorbidity; Endometriosis; Hypercholesterolemia.

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Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Age distributions of adenomyosis, endometriosis, and benign ovarian tumor.
See this image and copyright information in PMC

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