Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec;38(6):2585-2592.
doi: 10.1007/s10792-017-0772-3. Epub 2017 Nov 28.

Standard, transepithelial and iontophoresis corneal cross-linking: clinical analysis of three surgical techniques

Settimio Rossi  1 , Carmine Santamaria  2 , Rosa Boccia  3 , Luigi De Rosa  3 , Francesco Maria D'Alterio  3 , Francesca Simonelli  3 , Giuseppe De Rosa  3
Affiliations

Standard, transepithelial and iontophoresis corneal cross-linking: clinical analysis of three surgical techniques

Settimio Rossi et al. Int Ophthalmol. 2018 Dec.

Abstract

Background: To evaluate the clinical results of standard, transepithelial (TE) and iontophoresis (I) corneal cross-linking (CXL), in patients with progressive keratoconus.

Methods: Thirty eyes of 30 patients with progressive keratoconus treated by CXL (10 by standard-CXL, 10 by TE-CXL and 10 by I-TE-CXL) with 12 months of follow-up. Pre- and postoperative ophthalmologic testing were: uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), refractive examination (spherical error, spherical equivalent), corneal topography (corneal astigmatism, simulated maximum, minimum and average keratometry), aberrometry (coma and spherical aberration), pachymetry and endothelial cell density.

Results: In all groups, UDVA and CDVA improved significantly after treatment. Furthermore, a significant improvement in spherical error, spherical equivalent, topographic and aberrometric outcomes was observed in 3 groups at 1 year posttreatment. No significant variations were recorded in corneal thickness and endothelial cellular density.

Conclusion: Our results showed efficacy, clinical and refractive stability after standard-CXL, TE-CXL and iontophoresis-CXL.

Keywords: Corneal cross-linking; Corneal disease; Corneal topography; Iontophoresis; Keratoconus.

PubMed Disclaimer

References

    1. J Ophthalmic Vis Res. 2015 Jan-Mar;10(1):77-80 - PubMed
    1. J Refract Surg. 2003 Mar-Apr;19(2 Suppl):S227-30 - PubMed
    1. J Refract Surg. 2014 Nov;30(11):746-53 - PubMed
    1. Curr Eye Res. 2004 Jul;29(1):35-40 - PubMed
    1. Clin Ter. 2015;166(4):e254-6 - PubMed

Substances

LinkOut - more resources