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. 2018 Jan;29(1):e13.
doi: 10.3802/jgo.2018.29.e13.

Prognostic significance of normal-sized ovary in advanced serous epithelial ovarian cancer

E Sun Paik  1 , Ji Hye Kim  1 , Tae Joong Kim  1 , Jeong Won Lee  1 , Byoung Gie Kim  1 , Duk Soo Bae  1 , Chel Hun Choi  2
Affiliations

Prognostic significance of normal-sized ovary in advanced serous epithelial ovarian cancer

E Sun Paik et al. J Gynecol Oncol. 2018 Jan.

Abstract

Objective: We compared survival outcomes of advanced serous type epithelial ovarian cancer (EOC) patients with normal-sized ovaries and enlarged-ovarian tumors by propensity score matching analysis.

Methods: The medical records of EOC patients treated at Samsung Medical Center between 2002 and 2015 were reviewed retrospectively. We investigated EOC patients with high grade serous type histology and International Federation of Gynecology and Obstetrics (FIGO) stage IIIB, IIIC, or IV who underwent primary debulking surgery (PDS) and adjuvant chemotherapy to identify patients with normal-sized ovaries. Propensity score matching was performed to compare patients with normal-sized ovaries to patients with enlarged-ovarian tumors (ratio, 1:3) according to age, FIGO stage, initial cancer antigen (CA)-125 level, and residual disease status after PDS.

Results: Of the 419 EOC patients, 48 patients had normal-sized ovary. Patients with enlarged-ovarian tumor were younger (54.0±10.3 vs. 58.4±9.2 years, p=0.005) than those with normal-sized ovary, and there was a statistically significant difference in residual disease status between the 2 groups. In total cohort with a median follow-up period of 43 months (range, 3-164 months), inferior overall survival (OS) was shown in the normal-sized ovary group (median OS, 71.2 vs. 41.4 months; p=0.003). After propensity score matching, the group with normal-sized ovary showed inferior OS compared to the group with enlarged-ovarian tumor (median OS, 72.1 vs. 41.4 months; p=0.031). In multivariate analysis for OS, normal-sized ovary remained a significant factor.

Conclusion: Normal-sized ovary was associated with poor OS compared with the common presentation of enlarged ovaries in EOC, independent of CA-125 level or residual disease.

Keywords: Matched-Pair Analysis; Normal-sized Ovarian Carcinoma; Ovarian Neoplasms; Prognosis; Propensity Score.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curve of (A) PFS and (B) OS in all patients. OS, overall survival; PFS, progression-free survival.
Fig. 2
Fig. 2
Kaplan-Meier curve of (A) PFS and (B) OS in patients after propensity score matching. OS, overall survival; PFS, progression-free survival.
See this image and copyright information in PMC

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. - PubMed
    1. Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol. 2012;13:790–801. - PubMed
    1. Feuer GA, Shevchuk M, Calanog A. Normal-sized ovary carcinoma syndrome. Obstet Gynecol. 1989;73:786–792. - PubMed
    1. Wang C, Li L, Qi X. Analysis of the clinical characteristics and prognostic factors with primary normal-sized epithelial ovarian carcinoma syndrome. Zhonghua Fu Chan Ke Za Zhi. 2000;35:420–422. - PubMed
    1. Yamazaki T, Hatano H, Suzuki A, Sugase M, Nakamura M, Sekiya M, et al. Normal-sized ovary carcinoma syndrome: histopathological analysis of 14 cases. Nippon Sanka Fujinka Gakkai Zasshi. 1995;47:27–34. - PubMed

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